| Annotated protein: | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein). Gene symbol: KIDINS220. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9EQG6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIDINS220 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic cerebral cortex, glutamatergic |
| Annotated paper: | Arevalo JC, et al. "The ARMS/Kidins220 scaffold protein modulates synaptic transmission" Mol Cell Neurosci. 2010 Oct;45(2):92-100 PMID:20547223 |
| Figure(s): | Figure 1, 4 |
| Annotation description: | Figure 1b: ARMS (gene KIDINS220) is detected in synaptic biochemical fractions from hippocampal neurons, co-migrating with Trk receptors and GluA1 (GRIA1) in various subfractions from P2. Figure 1c: immunogold EM showed of hippocampal CA1 showed ARMS localized to endomembranes in the dendritic shaft and spine. No presynaptic localization was observed. Figure 4: immunofluorescence imaging of 15DIV hippocampal neurons showed intracellular GluA1 co-localized with ARMS whereas surface GluA1 did not. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | antibody source @ PMID:11150334 |
| SynGO annotation ID: | 5282 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |