| Annotated protein: | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65). Gene symbol: APBB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P46933 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ APBB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Masin M, et al. "Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function" J Biol Chem. 2006 Feb 17;281(7):4100-8 PMID:16330549 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5: "The adaptor protein Fe65 (APBB1) is present in Schaffer collaterals/CA1 dendritic spine hippocampal synapses where it colocalizes with P2X2 subunits. Immunogold localization of Fe65 using Fe65-32 (A-C) or Fe65-35 (D-G) antibodies. Gold particles were found both at the pre- and postsynaptic specialization of excitatory hippocampal synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5278 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |