| Annotated protein: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1). Gene symbol: PIN1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q13526 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Xu L, et al. "Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease" Neural Plast. 2017;2017:3270725 PMID:28458925 |
| Figure(s): | Fig.1, Fig.2 |
| Annotation description: | Fig.1 Pin1 protein is present in the PSD fraction derived from cortical tissues of human brain. Literal: "Pin1 proteins exist in detergent-resistant dendritic rafts and PSD fractions" Fig. 2 Pin1 protein, in cortical neurons partially colocalyze with NR1 and Shank3 proteins" Literal: "Pin1 proteins also partly colocalized with NR1 proteins along with Shank3 proteins at the dendritic spines of excitatory neuron" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 527 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |