| Annotated protein: | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1). Gene symbol: LIMK1. Taxonomy: Homo sapiens (Human). Uniprot ID: P53667 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LIMK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | George J, et al. "Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity" Elife. 2015 Apr 17;4:e06327 PMID:25884247 |
| Figure(s): | Figure 1, 2 |
| Annotation description: | Figure 1, 2 (and suppl.): immunofluorescence imaging of overexpressed myc-tagged LIMK1 in cultured hippocampal neurons showed enrichment in dendritic spines. Using various mutant constructs, authors showed that targeting to the dendritic spine is driven by LIMK1's palmitoyl-motif. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5266 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |