Annotated protein:	Sushi domain-containing protein 4. Gene symbol: SUSD4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BH32
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SynGO gene info:	SynGO data @ SUSD4
Ontology domain:	Biological Process
SynGO term:	regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149)
Synapse type(s):	cerebellum
Annotated paper:	Gonzalez-Calvo I, et al. "Sushi domain-containing protein 4 controls synaptic plasticity and motor learning" Elife. 2021 Mar 4;10:e65712 PMID:33661101
Figure(s):	Figure 4, 5
Annotation description:	Figure 4: SUSD4 loss-of-function leads to deficient activity-dependent degradation of GluA2 (GRIA2). "In slices from Susd4 KO mice, this activity-dependent degradation of GluA2 was completely absent. Additionally, the chemical induction of LTD had no effect on the total protein levels of GluD2, another synaptic receptor highly present at PF/PC postsynaptic densities, either in slices from WT or from Susd4 KO mice (Figure 4-figure supplement 1). Thus, SUSD4 specifically controls the activity-dependent degradation of GluA2-containing AMPA receptors during LTD." Further, SUSD4 interactors and co-localized with AMPA receptor subunit GluA2 (Fig. 4-s2) and interacts with SUSD4 interacts with NEDD4 ubiquitin ligases (Fig. 5).
Evidence tracking, Biological System:	Cultured neurons Intact tissue
Evidence tracking, Protein Targeting:	Over-expression Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:	Confocal IP + WB/MSMS Whole-cell patch clamp
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	5260
Dataset release (version):	20231201
View annotation as GO-CAM model: