| Annotated protein: | Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R). Gene symbol: SIGMAR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9R0C9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIGMAR1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tsai SY, et al. "Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway" Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22468-73 PMID:20018732 |
| Figure(s): | Figure 1, 2, 4 |
| Annotation description: | Figure 1: Sigma-1 receptor (SIGMAR1) knockdown inhibits synapse formation in cultured hippocampal neurons. "In general, silencing of Sig-1R expression increased the length of protrusions by 59% on DIV 16 and 159% on DIV 22, respectively. These results suggest a dysregulation of stage-dependent signalings for actin compartmentalization/polymerization in Sig-1R-deficient neurons." Figure 2: Sigma-1 receptor knockdown inhibits activation of Rac1 Rho GTPase. Figure 4: Caspase-3-Resistant TIAM1 construct rescues the spine formation in Sigma-1 receptor knockdown neurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5250 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |