| Annotated protein: | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII). Gene symbol: SYT17. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9BSW7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYT17 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ruhl DA, et al. "Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways" Nat Commun. 2019 Aug 6;10(1):3532 PMID:31387992 |
| Figure(s): | Figure 7a |
| Annotation description: | Figure 1: overexpression of a syt-17-pHluorin construct in 3DIV hippocampal neurons showed synaptotagmin-17 (SYT17) at dendritic puncta, co-localized with endosomal marker GFP-RAB5 (marker for early endosomes). Figure 7: to establish synaptic localization of SYT17, higher-resolution immunofluorescence labeling in 14 14DIV hippocampal neurons showed postsynaptic co-localization of endogenous AMPA receptors with overexpressed RAB5 and SYT17. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5243 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |