| Annotated protein: | MOB-like protein phocein (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3). Gene symbol: MOB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6PEB6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MOB4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic cerebellum, glutamatergic |
| Annotated paper: | Haeberle AM, et al. "Immunogold localization of phocein in dendritic spines" J Comp Neurol. 2006 Mar 20;495(3):336-50 PMID:16440294 |
| Figure(s): | Figures 3-10 |
| Annotation description: | Figures 3-10: extensive immunogold EM showed Phocein (MOB4) localization to postsynapses (but never presynaptic terminals). subcellular localization was observed throughout the dendritic spine. authors summarize; "The present immunocytochemical study shows that phocein is strictly targeted to the dendritic spines of hippocampal pyramidal neurons and cerebellar Purkinje cells that establish asymmetric synapses with excitatory afferents in the adult brain." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Phocein characterization & localization to dendritic spines @ PMID:11251078 further EM evidence for Phocein postsynaptic localization (same authors as primary PMID annotated here) @ PMID:17853115 |
| SynGO annotation ID: | 5242 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |