| Annotated protein: | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]. Gene symbol: HTT. Taxonomy: Homo sapiens (Human). Uniprot ID: P42858 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTT |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | DiFiglia M, et al. "Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons" Neuron. 1995 May;14(5):1075-81 PMID:7748555 |
| Figure(s): | fig 5h |
| Annotation description: | Authors performed immunogold EM in synaptosomal fractions from human cortex and detected huntingtin within the postsynaptic cytoplasm. 13/6/2017 Pim - LIteral: "Immunogold labeling of a synaptosome fraction from the human cortex demonstrates the presence of gold particles around vesicles (arrows) in a presynaptic profile and within the **matrix of the cytoplasm (small arrows) postsynaptically**." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 524 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |