| Annotated protein: | Transmembrane and ubiquitin-like domain-containing protein 1 (Hepatocyte odd protein shuttling protein) [Cleaved into: iHOPS]. Gene symbol: TMUB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q53AQ4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TMUB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic recycling endosome membrane (GO:0098944) |
| Annotated paper: | Yang H, et al. "Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors" PLoS One. 2008 Jul 30;3(7):e2809 PMID:18665261 |
| Figure(s): | Figure 2, 4, 7 |
| Annotation description: | Figure 2g: TMUB1 and GluR2 (GRIA2) were both enriched in synaptosomal membrane fractions and had a similar enrichment pattern over various biochemical fractions prepared from mouse brains. Figure 2b: confocal imaging of immunofluorescence labeling for TMUB1 and PSD-95 (DLG4) in cultured hippocampal rat neurons showed partial co-localization. Figure 7: A large portion of Tmub1/HOPS colocalizes with GluR2 at recycling endosomes. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5231 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |