| Annotated protein: | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein). Gene symbol: SYNCRIP. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q7TP47 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNCRIP |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Santos SD, et al. "Proteomic analysis of an interactome for long-form AMPA receptor subunits" J Proteome Res. 2010 Apr 5;9(4):1670-82 PMID:20131911 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4a,b: pulldowns of GluR1 (GRIA1) and GluR4 (GRIA4) in rat cerebellum tissue retrieved SYNCRIP. Figure 4c: confocal imaging of immunofluorescence labeling for SYNCRIP, surface-GluR1 (GRIA1) and PSD-95 (DLG4) in cultured hippocampal neurons showed localization of SYNCRIP to the postsynaptic density. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 3: confocal imaging showed SYNCRIP localization to dendritic spines in cultured hippocampal neurons @ PMID:30918483 |
| SynGO annotation ID: | 5229 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |