| Annotated protein: | Calreticulin (CALBP) (CRP55) (Calcium-binding protein 3) (CABP3) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP). Gene symbol: CALR. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P18418 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CALR |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic ER |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Gurth CM, et al. "Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway" Sci Rep. 2020 Nov 25;10(1):20576 PMID:33239744 |
| Figure(s): | Figure S1 |
| Annotation description: | Figure S1c: STED super-resolution microscopy of hippocampal primary neurons with antibody labeling of endogenous calreticulin (gene CALR, an ER marker), postsynaptic density marker Homer1 and actin (phalloidin, in confocal mode) showed calreticulin at the dendritic shaft and at postsynapses in close proximity to Homer1. Authors observed that "While the synaptopodin signal was clearly concentrated in the spine head, calreticulin, ERGIC53 and TGN38 appeared as sparse, but distinct, spots in both the dendritic shaft and spines." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5221 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |