| Annotated protein: | Engulfment and cell motility protein 1 (Protein ced-12 homolog). Gene symbol: ELMO1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BPU7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ELMO1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Morikawa M, et al. "The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation" Cell Rep. 2018 Jun 26;23(13):3864-3877 PMID:29949770 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4: Time-lapse fluorescence micrographs of ELMO1-TagRFP-transfected dissociated hippocampal neurons of wildtype and KIF21B knockout mice at DIV 21 before (0') and after (20') chemical LTD induction with NMDA. Imaging data shows ELMO1 at dendritic spines and translocating to the dendritic shaft upon stimulus. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5204 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |