| Annotated protein: | Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4). Gene symbol: PRRT1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35449 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRRT1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | van der Spek SJF, et al. "Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition" Cells. 2022 Nov 17;11(22):3648 PMID:36429079 |
| Figure(s): | Figure 4, S5 |
| Annotation description: | Figure 4, S5: STED super-resolution microscopy of hippocampal neurons stained for SynDIG4 (PRRT1), TARP-γ8 (CACNG8) and Homer (HOMER1) showed localization of SynDIG4 to postsynaptic densities. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5196 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |