| Annotated protein: | Cannabinoid receptor 2 (CB-2) (CB2) (rCB2). Gene symbol: CNR2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QZN9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNR2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Brusco A, et al. "Ultrastructural localization of neuronal brain CB2 cannabinoid receptors" Ann N Y Acad Sci. 2008 Oct;1139:450-7 PMID:18991892 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2: electron microscopy of immunoperoxidase labeling for CB2 receptors (CB2-R, gene CNR2) in hippocampal neurons showed localization to the plasma membrane of dendrites and postsynapses. No presynaptic localization was observed. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. authors comment on non-synaptic localization: "CB2-R immunoreactivity (CB2-IR) was observed as diffused electron-dense deposits in some but not all neuronal cell bodies throughout the analyzed area of the hippocampus. In those neuronal cell bodies where CB2-IR was present, it was mostly associated with the rough endoplasmic reticulum as well as with the Golgi apparatus, indicating its endogenous synthesis (Fig. 2A). In the same area, CB2-IR was also present in small and medium-size dendrites (Fig. 2B, C, and D), but it was not observed either in axons or axon terminals (Fig. 2B and C)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5173 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |