| Annotated protein: | Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Vanilloid receptor type 1-like). Gene symbol: TRPV1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35433 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TRPV1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Annotated paper: | Toth A, et al. "Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain" Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):162-8 PMID:15857679 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4: immunogold EM imaging of rat brain slices showed TRPV1 mostly but not exclusively in the post-synaptic spines and this finding was in agreement with the staining of dendrites seen on the confocal images. TRPV1 was also localized to astrocytes and pericytes. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5172 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |