| Annotated protein: | Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1). Gene symbol: FAAH. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08914 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FAAH |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (GO:0150036) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zimmermann T, et al. "Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses" Neuropsychopharmacology. 2019 Jul;44(8):1377-1388 PMID:30532004 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | Figure 2: Overexpression of FAAH in hippocampal glutamatergic neurons leads to increased degradation of anandamide (AEA) and palmitoylethanolamide (PEA). Figure 3: Elevated FAAH levels in hippocampal pyramidal neurons increase LTP, but not eLTD, iLTD, DSE, or DSI in hippocampal CA1 pyramidal cells. "This approach led to specific FAAH overexpression at the postsynaptic site of CA1-CA3 neurons, to increased FAAH enzymatic activity, and, in consequence, to decreased hippocampal levels of AEA and palmitoylethanolamide (PEA), but the levels of the second major endocannabinoid 2-arachidonoyl glycerol (2-AG) and of oleoylethanolamide (OEA) were unchanged." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Mass-spectrometry |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5164 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |