| Annotated protein: | PDZ and LIM domain 5. Gene symbol: PDLIM5. Taxonomy: Gallus gallus (Chicken). Uniprot ID: F1NTC8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PDLIM5 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Gardezi SR, et al. "PDLIM5 is not a neuronal CaV2.2 adaptor protein" Nat Neurosci. 2009 Aug;12(8):957-8; author reply 958 PMID:19636345 |
| Figure(s): | Figure S2 |
| Annotation description: | Figure S2a: "PDLIM5 is present at presynaptic terminals. Isolated chick ciliary ganglion neuron with its calyx-type presynaptic nerve terminal double stained for SV2 and PDLIM5." Figure S2b: "Characterization of presynaptic membrane fractions. Synaptosomes were isolated by discontinuous sucrose g isolated by discontinuous sucrose gradient radient centrifugation and were centrifugation and were lysed by osmotic shock to generate a presynaptic membrane fraction P2" that was enriched in three presynaptic markers: syntaxin 1, SNAP-25 and synaptotagmin. This fraction was also enriched in PDLIM5." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 4: PDLIM5 partially co-localized with synaptophysin (SYP) in cultured hippocampal neurons @ PMID:19900557 |
| SynGO annotation ID: | 5151 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |