| Annotated protein: | PDZ and LIM domain protein 4 (H-REV18) (LIM protein RIL) (RIT-18) (Reversion-induced LIM protein). Gene symbol: PDLIM4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P36202 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PDLIM4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schulz TW, et al. "Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL" J Neurosci. 2004 Sep 29;24(39):8584-94 PMID:15456832 |
| Figure(s): | Figure 7, 8 |
| Annotation description: | Figure 1, 2, 3: RIL (PDLIM4) interacts with AMPA receptors (GRIA1, 2/3) and α-actinin (ACTN1 and ACTN2). Figure 7, 8: RIL (PDLIM4) overexpression increased the abundance of GRIA1-containing receptors in dendritic spines and enhanced AMPA receptor-mediated synaptic currents in hippocampal primary neurons. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5147 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |