| Annotated protein: | PDZ and LIM domain protein 4 (H-REV18) (LIM protein RIL) (RIT-18) (Reversion-induced LIM protein). Gene symbol: PDLIM4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P36202 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PDLIM4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schulz TW, et al. "Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL" J Neurosci. 2004 Sep 29;24(39):8584-94 PMID:15456832 |
| Figure(s): | Figure 1, 2, 3 |
| Annotation description: | Figure 1, 2, 3: RIL (PDLIM4) interacts with AMPA receptors (GRIA1, 2/3) and α-actinin (ACTN1 and ACTN2). Figure 3b: RIL (PDLIM4) is enriched in PSD biochemical fractions from adult rat brain as compared to homogenate and synaptosomes. Figure 3c: "RIL immunoreactivity was concentrated in dendritic spines and showed partial colocalization with the presynaptic vesicular protein SV2 (Buckley and Kelly, 1985), confirming that in hippocampal principal neurons, RIL is localized mainly to the postsynaptic sites of synapses." |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5146 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |