| Annotated protein: | Actinin alpha 2. Gene symbol: ACTN2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZCV0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ACTN2 |
| Ontology domain: | Biological Process |
| SynGO term: | structural constituent of postsynaptic actin cytoskeleton (GO:0098973) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hodges JL, et al. "alpha-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons" PLoS One. 2014 Jul 9;9(7):e101770 PMID:25007055 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6: confocal imaging of α-actinin-2 (ACTN2) knockdown constructs in 6DIV hippocampal neurons showed formation of dendritic spines was strongly impaired. authors conclude: "We found that spines in neurons lacking α-actinin-2 are largely devoid of detectable actin filament bundles, suggesting that α-actinin-2 helps to form a template for the hierarchical addition of PSD molecules within the spine." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5145 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |