Annotated protein:E3 SUMO-protein ligase PIAS1 (EC 2.3.2.27) (DEAD/H box-binding protein 1) (Protein inhibitor of activated STAT protein 1) (RING-type E3 ubiquitin transferase PIAS1). Gene symbol: PIAS1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88907
antibody wiki:
SynGO gene info:SynGO data @ PIAS1
Ontology domain:Cellular Component
SynGO term:presynaptic cytosol (GO:0099523)
Synapse type(s):hippocampus, glutamatergic
cerebral cortex, glutamatergic
Annotated paper:Conz A, et al. "Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons" Eur J Histochem. 2021 Aug 11;65(s1):3241 PMID:34459572
Figure(s):Figure 1, 3
Annotation description:Figure 1, 3: cultured hippocampal and cortical neurons were stained for PIAS1, synaptophysin (SYP) and PSD95 (DLG4) and imaged using both confocal and SIM super-resolution microscopy. PIAS1 was omnipresent at e.g. nucleus and cytoplasm, but also showed partial co-localization with pre- and post-synaptic marker proteins.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Super resolution
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5141
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology