| Annotated protein: | Coiled-coil and C2 domain-containing protein 1A (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1). Gene symbol: CC2D1A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8K1A6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CC2D1A |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Annotated paper: | Yang CY, et al. "Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation" J Neurosci. 2019 Jun 19;39(25):4959-4975 PMID:30992372 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1a: CC2D1A (aka. Freud-1) protein expression in hippocampal CA1 tissue was lowest at E18 and postnatal day 1 as compared to young and adult mice. Figure 1b: biochemical fractions showed CC2D1A was present at both pre- and post-synapse. Figure 6: Effects of Cc2d1a deletion on expression of AMPAR and NMDAR subunits, mEPSCs, and evoked NMDAR-mediated EPSCs in the hippocampal CA1 region. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Electrophysiology (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Cc2d1a was detected in synaptosomes (includes knockout control for the antibody). Cc2d1a knockout affects both inhibitory and excitatory synapses, affects the synapse maturation process and synaptic vesicle endocytosis. @ PMID:21273312 |
| SynGO annotation ID: | 5128 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |