| Annotated protein: | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7). Gene symbol: SENP7. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BUH8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SENP7 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Colnaghi L, et al. "Neuronal Localization of SENP Proteins with Super Resolution Microscopy" Brain Sci. 2020 Oct 25;10(11):778 PMID:33113832 |
| Figure(s): | Figure 3 |
| Annotation description: | "we stained cultured hippocampal neurons with antibodies directed against SENP7, MAP2, and the synaptic markers drebrin and synaptophysin. We acquired images using both confocal microscopy with a 40× objective (Figure 3A,G) and 3D-SIM microscopy (Figure 3B,C,H,I and Supplemental Figure S3A,B). Similarly to SENP1 and SENP6, we found that SENP7 is both a nuclear and cytoplasmic protein. Outside the nucleus, it partially colocalizes with synaptic markers, as indicated by Mander's and Pearson's correlation coefficients (Figure 3D-F,J-L)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5119 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |