| Annotated protein: | Rho GTPase activating protein 33. Gene symbol: ARHGAP33. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A8I6AJS5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGAP33 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kim Y, et al. "SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons" J Biol Chem. 2013 Oct 11;288(41):29453-66 PMID:24003235 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4a-d: SNX26 (ARHGAP33) and PSD95 (DLG4) interact through SNX26-PX and -RhoGAP domains. Figure g,h: overexpressed SNX26 (ARHGAP33) co-localized with PSD95 (DLG4) at dendritic spines in cultured hippocampal neurons. Endogenous SNX26 targeted with an antibody showed (reduced) co-localization with PSD95. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5110 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |