Annotated protein:	Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (mCPEB-3). Gene symbol: CPEB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TN99
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SynGO gene info:	SynGO data @ CPEB3
Ontology domain:	Biological Process
SynGO term:	regulation of postsynapse assembly (GO:0150052)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Pavlopoulos E, et al. "Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage" Cell. 2011 Dec 9;147(6):1369-83 PMID:22153079
Figure(s):	Figure 7
Annotation description:	Figure 7: confocal imaging of dendritic spines in cultured hippocampal neurons (11DIV) expressing controls, wildtype CPEB3 and various CPEB3 mutants showed that CPEB3 overexpression strongly decreased spine density but not in CPEB3-Δubiquitination. "However, expressing CPEB3-UbKO resulted in pronounced increase of number of spines and filopodia, whereas CPEB3 fused to either DsRed or SUMO resulted in a phenotype similar to wild type CPEB3. Taken together, our data suggest that the ability of Neurl1 to ubiquitinate CPEB3 is a limiting factor and facilitates hippocampal synaptic plasticity and hippocampal-dependent memory by modulating CPEB3 translational activity through ubiquitination with consequent induction of an increase of GluA1 and GluA2 protein levels and the formation of new spines."
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	5100
Dataset release (version):	20231201
View annotation as GO-CAM model: