Annotated protein:	Actin-associated protein FAM107A. Gene symbol: FAM107A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q78TU8
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SynGO gene info:	SynGO data @ FAM107A
Ontology domain:	Biological Process
SynGO term:	regulation of postsynapse assembly (GO:0150052)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Schmidt MV, et al. "Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition" Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17213-8 PMID:21969592
Figure(s):	Figure 5
Annotation description:	Golgi-Cox staining revealed a significant reduction of spine density on apical dendrites of CA3 and CA1 pyramidal neurons of mice with increased DRR1 expression (Fig. 5B). "Mechanistically, we consider it unlikely that DRR1 acts indirectly on actin, as we observed the bundling effect with purified recombinant DRR1 and purified actin preparations. DRR1 may instead act similarly to the known actin cross-linking proteins β-actinin, filamin, or spectrin (5, 13), with either two binding sites for actin or the ability to dimerize. ... Because enhanced levels of DRR1 in neuronal cells hampered neurite outgrowth, but had no effect on already developed neurites, it is likely that DRR1 affects the formation and stability of spines, a process recently discovered as essential for learning and memory"
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	5086
Dataset release (version):	20231201
View annotation as GO-CAM model: