Annotated protein:	Nectin-3 (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113). Gene symbol: NECTIN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JLB9
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SynGO gene info:	SynGO data @ NECTIN3
Ontology domain:	Biological Process
SynGO term:	regulation of postsynapse assembly (GO:0150052)
Synapse type(s):	hippocampus
Annotated paper:	Wang XX, et al. "Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory" Transl Psychiatry. 2017 Sep 5;7(9):e1228 PMID:28872640
Figure(s):	Figure 4
Annotation description:	"We further examined the impact of nectin-3 downregulation on spine density in new DG granule cells (Figure 4), and observed that nectin-3 knockdown evoked a reduction of spines, especially thin spines, in the medial ML (thin: t10=2.441, P=0.035; total: t10=2.318, P=0.043; independent t-test). In comparison, consistent with our previous findings,19 spine density in the medial ML of DG remained unchanged in adult mice with early-life stress exposure (Supplementary Figure S7)."
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	RNAi / shRNA
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Additional literature:	"Figure 5: Nectin-3 knockdown reduced dendritic spine density in CA3 pyramidal neurons." "Postnatally stressed adult mice had reduced spine density in CA3 neurons, and nectin-3 overexpression restored the number of spines (Fig. 7b)." @ PMID:23644483
SynGO annotation ID:	5083
Dataset release (version):	20231201
View annotation as GO-CAM model: