| Annotated protein: | Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Keratinocyte lipid-binding protein) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP). Gene symbol: FABP5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q05816 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FABP5 |
| Ontology domain: | Biological Process |
| SynGO term: | retrograde trans-synaptic signaling by endocannabinoid (GO:0098921) |
| Synapse type(s): | brainstem, glutamatergic |
| Annotated paper: | Haj-Dahmane S, et al. "Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses" Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3482-3487 PMID:29531087 |
| Figure(s): | Figure 1, 2, 4 |
| Annotation description: | The inherent lipophilicity of endocannabinoids (eCBs) limits their transport across aqueous compartments, including the cytosol and synaptic cleft. Fatty acid-binding proteins (FABPs) are chaperones that facilitate the intracellular trafficking of eCBs to their respective catabolic enzymes and nuclear receptors (see also PMID:19307565). Figure 1, 2: pharmacological inhibition of FABP5 abolishes both phasic and tonic endocannabinoid-mediated control of excitatory synaptic transmission in the dorsal raphe nucleus. Figure 4: genetic deletion of FABP5 also abolishes phasic and tonic Arachidonoylglycerol (2-AG) signaling. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | FABP5 is involved in endocannabinoid signaling at striatum synapses @ PMID:35875351 characterization of FABPs as intracellular transporters of endocannabinoid anandamide (aka. AEA) @ PMID:19307565 |
| SynGO annotation ID: | 5082 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |