| Annotated protein: | Immunoglobulin superfamily member 11 (IgSF11). Gene symbol: IGSF11. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5U2P2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IGSF11 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jang S, et al. "Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity" Nat Neurosci. 2016 Jan;19(1):84-93 PMID:26595655 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1: expression of IgSF11 increases during rat brain development, is enriched in PSD biochemical fractions, interacts with PSD-95 (DLG4) in HEK293T cells and in vivo, co-localizes with PSD-95 at dendritic spines of cultured rat hippocampal neurons. Based on the known transmembrane topology of this protein (Figure 1a), "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5060 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |