| Annotated protein: | IQ motif containing GTPase activating protein 1. Gene symbol: IQGAP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: G3V7Q7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IQGAP1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Jausoro I, et al. "Regulation of spine density and morphology by IQGAP1 protein domains" PLoS One. 2013;8(2):e56574 PMID:23441206 |
| Figure(s): | Figure 2, 3, 5 |
| Annotation description: | Figure 2, 3: Confocal imaging of cultured hippocampal neurons showed over-expression of IQGAP1 stimulated spine formation and increased spine head size. The effect was strongly reduced in an IQGAP1 mutant lacking the CHD domain. Figure 5: IQGAP1 mutants that lacks C-terminus also stimulates spine formation; deletion of this domain does not prevent the stimulatory effect of IQGAP1 on spine number or spine head size. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 4: Region-specific decrease of spine density after deletion of IQGAP1 @ PMID:21653857 |
| SynGO annotation ID: | 5051 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |