| Annotated protein: | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Inositol polyphosphate 4-phosphatase-1) (4-Ptase-1) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66). Gene symbol: INPP4A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EPW0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ INPP4A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Sasaki J, et al. "The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death" Nature. 2010 May 27;465(7297):497-501 PMID:20463662 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4: biochemical fractions of striata from wildtype and INPP4A-knockout mice showed INPP4A localized to the PSD and that its knockout increased NR1 and (phosphorylated) NR2B expression levels |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5044 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |