Annotated protein:Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Inositol polyphosphate 4-phosphatase-1) (4-Ptase-1) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66). Gene symbol: INPP4A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EPW0
antibody wiki:
SynGO gene info:SynGO data @ INPP4A
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Synapse type(s):striatum, glutamatergic
Annotated paper:Sasaki J, et al. "The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death" Nature. 2010 May 27;465(7297):497-501 PMID:20463662
Figure(s):Figure 4
Annotation description:Figure 4: biochemical fractions of striata from wildtype and INPP4A-knockout mice showed INPP4A localized to the PSD and that its knockout increased NR1 and (phosphorylated) NR2B expression levels
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Antibody (detection)
Evidence tracking, Experiment Assay:Biochemical fractionation (generic)
Western blot
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5044
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology