Annotated protein:APC regulator of WNT signaling pathway 2. Gene symbol: APC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A205
antibody wiki:
SynGO gene info:SynGO data @ APC2
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):brain
Annotated paper:Fu AK, et al. "APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity" Nat Neurosci. 2011 Feb;14(2):181-9 PMID:21186356
Figure(s):Fig. 5d
Annotation description:The authors found that APC2 is concentrated in the detergent-resistant post-synaptic fractions of adult rat brain, which suggests that there is a tight association between APC and postsynaptic proteins (Fig. 5d).

28/8/2017 Pim
- Functional data shows that APC mediates ubituitination of AMPARs, and " Reduction of synaptic strength by ephrin-A1 or chronic treatment of bicuculline depends on APCCdh1-dependent proteasome degradation pathway" This is functional evidendce that APC is indeed localizated in the postsynapse.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Western blot
Biochemical fractionation (generic)
Annotator(s):Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491)
Vittoria Mariano (ORCID:0000-0002-9848-0262)
Achsel Tilmann (ORCID:0000-0002-1190-4481)
Claudia Bagni (ORCID:0000-0002-4419-210X)
Lab:Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
SynGO annotation ID:504
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology