| Annotated protein: | Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1). Gene symbol: TRPC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QX01 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TRPC1 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kougioumoutzakis A, et al. "TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons" Mol Brain. 2020 Jan 29;13(1):12 PMID:31996247 |
| Figure(s): | Figure 3, 6 |
| Annotation description: | Figure 3: reverse IP of mGluR1a (GRM1) and TRPC1 in HEK-293 cells and additional TRPC1 pulldown in hippocampi showed these proteins can interact. Figure 6: in stratum interneurons, siRNA knockdown of TRPC1 reduced the amplitude of slow EPSCs. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | mGluR1-evoked slow EPSC is mediated by TRPC1 @ PMID:14614461 |
| SynGO annotation ID: | 5037 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |