| Annotated protein: | Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1). Gene symbol: TRPC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QX01 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TRPC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Kim SJ, et al. "Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1" Nature. 2003 Nov 20;426(6964):285-91 PMID:14614461 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1: immunogold labeling of TRPC1 and electron microscopy of the cerebellum showed postsynaptic and, to a lesser extend, presynaptic localization. Partial co-localization was observed for immunogold labelling for TRPC1 (5 nm) and mGluR1α /GRM1 (10 nm). Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5036 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |