| Annotated protein: | Dendrin. Gene symbol: DDN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P50617 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DDN |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | spinal cord |
| Annotated paper: | Juric M, et al. "Increased expression of dendrin in the dorsal horn of the spinal cord during stress is regulated by sex hormones" Neuropeptides. 2021 Apr;86:102126 PMID:33524899 |
| Figure(s): | Figure 7 |
| Annotation description: | "Transmission electron microscopy confirmed dendrin immunoreactivity in the dorsal horn neurons of the SC from M-SH-C rats, by using immunogold staining. As expected, gold particles were found in the postsynaptic area as well as in the neuronal soma and nucleus. It seems that the immunoreaction was distributed randomly throughout the neuronal soma and nucleus. Although less numerous, the gold particles were found in the presynaptic area and axon terminals confirming the immunoreactivity for dendrin in these areas as well. The immunoreaction in these areas usually was distributed near the presynaptic membrane close to synaptic vesicles and mitochondria (Fig. 7)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5031 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |