| Annotated protein: | RNA-binding protein FXR1 (FXR1P) (mFxr1p). Gene symbol: FXR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61584 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FXR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Wang GX, et al. "Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses" Elife. 2016 Oct 22;5:e20560 PMID:27770568 |
| Figure(s): | fig. 7 |
| Annotation description: | - Authors use SubSynMAP, a novel combination of previously developed volumetric super-resolution imaging of deconvolution array tomography (ATD). This technique uses the computational integration of wide-field fluorescence images to derive super-resolution level data on intracellular localization. - The authors state "The application of our synapse analysis method demonstrates that, across synapse classes and cortical layers, FXR1P and FXR2P unlike FMRP are preferentially localized to the post-synaptic region (Figure 7A-D, Figure 7-figure supplement 1A-D); but like FMRP, the distributions of FXR1P and FXR2P peak away from the synaptic cleft, suggesting an annotation against postsynapse. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | FXR1P cKO mice show a specific enhancement in L-LTP. Induced L-LTP by delivering four trains of HFS separated by a 20 s interval, L-LTP was increased at both 20-30 min and 3 hr post-HFS in the cKO (Figures 3D and 3E). Thus, loss of FXR1P specifically enhanced L-LTP, a form of plasticity that depends on new protein synthesis, without perturbing E-LTP or mGluR-dependent LTD. @ PMID:25456134 |
| SynGO annotation ID: | 503 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |