| Annotated protein: | Reelin (EC 3.4.21.-) (Reeler protein). Gene symbol: RELN. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q60841 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RELN |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Annotated paper: | Bosch C, et al. "Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells" Cereb Cortex. 2016 Oct 17;26(11):4282-4298 PMID:27624722 |
| Figure(s): | Figure 2, 3, 4 |
| Annotation description: | Figures 2-4: 3D structures of spines of 8-week-old WT, Reelin-OE (overexpressing) and Dab1-cKO GFP/DAB-labeled granule cells were reconstructed with FIB/SEM microscopy. Reelin and Dab1 both altered newborn granule cells dendritic spine morphology. Authors conclude from these analyses that "This proves that spines are more irregularly shaped in 8-9 weeks Reelin-OE and Dab1-cKO neurons, and suggests that spine structural maturation is affected by the Reelin signaling. Synapse sphericity was smaller in Reelin-OE mice at 8-9 weeks, indicating greater complexity (Fig.4d)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | dendrite complexity is severely reduced in homozygous mice deficient in Reelin @ PMID:14715136 higher density of synapses and structural complexity of both pre- and postsynaptic elements in transgenic mice overexpressing Reelin @ PMID:27303269 reelin application to adult mice hippocampal slices leads to enhanced glutamatergic transmission mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs) @ PMID:17167084 |
| SynGO annotation ID: | 5025 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |