| Annotated protein: | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5). Gene symbol: GNB5. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62881 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GNB5 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic membrane (GO:0042734) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Fajardo-Serrano A, et al. "Association of Rgs7/Gbeta5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons" Hippocampus. 2013 Dec;23(12):1231-45 PMID:23804514 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5: Electron micrographs of the stratum radiatum of the hippocampal CA1 region showing immunoparticles for Gβ5 (GNB5), as detected using a pre-embedding immunogold method. Synaptic localization was mostly to postsynapses with sparse labeling (5% of total particles) at presynaptic sites. Futher, extensive dendritic labeling was observed. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | GNB5 antibody @ PMID:21766168 |
| SynGO annotation ID: | 5016 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |