| Annotated protein: | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5). Gene symbol: GNB5. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62881 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GNB5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic membrane (GO:0045211) |
| Synapse type(s): | hippocampus striatum |
| Annotated paper: | Xie K, et al. "Gbeta5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems" Psychopharmacology (Berl). 2012 Feb;219(3):823-34 PMID:21766168 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2: Electron micrographs show immunolabeling for Gβ5 (GNB5) at the synapse in mouse striatum and hippocampus while labeling was abolished in knockout controls. "In striatum (A-C), and hippocampus (D-F) immunoparticles for Gβ5 were detected postsynaptically along the somatic plasma membrane (arrows), and intracellular sites (crossed arrows) of dendritic shafts (Den) and dendritic spines (s). In addition, immunoparticles for Gβ5 were detected at presynaptic sites, along the extrasynaptic plasma membrane (arrowheads) of axon terminals (at) establishing excitatory synapses with dendritic shafts or dendritic spines (s). Immunoreactivity for Gβ5 was completely absent in Gβ5-/-samples" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5014 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |