| Annotated protein: | Immunoglobulin superfamily member 21 (IgSF21). Gene symbol: IGSF21. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TNR6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IGSF21 |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling, modulating synaptic transmission (GO:0099550) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Tanabe Y, et al. "IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2alpha" Nat Commun. 2017 Sep 1;8(1):408 PMID:28864826 |
| Figure(s): | Figure 7 |
| Annotation description: | Figure 2-3: IgSF21 is a postsynaptic protein that interacts specifically with neurexin2α (gene NRXN2) and not any of the other neurexin isoforms. Figure 7: IgSF21 knockout reduces (but does not abolish) synaptic transmission. Authors propose that IgSF21 modulates synaptic transmission through trans-synaptic signaling via neurexin2α. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5007 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |