| Annotated protein: | Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha). Gene symbol: NRXN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q7X7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lin PY, et al. "Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus" Sci Adv. 2023 Jan 6;9(1):eadd8856 PMID:36608123 |
| Figure(s): | Figure 3 |
| Annotation description: | "Strikingly, the added "new" synapses that were induced by the deletion of Nrxn2 were more powerful and had a higher release probability than Nrxn2-containing synapses. The increase in release probability was again documented by three approaches: a decreased paired-pulse ratio (PPR) (Fig. 3E), a decreased coefficient of variation of synaptic responses (Fig. 3, F and J), and an enhanced inactivation rate of synaptic responses in the presence of MK-801 (Fig. 3, K to M)." Authors note that this is unexpected and in contrast to Nrxn2's well studied family members Nrxn1 and Nrxn3, where deletions cause impairments in synaptic transmission in both mouse and human neurons (e.g. PMID:26279266, PMID:26030848). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 1. Lentivirally expressed Neurexin-2β decreases GABAergic but not glutamatergic synaptic strength in cultured hippocampal neurons @ PMID:20471353 |
| SynGO annotation ID: | 5005 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |