| Annotated protein: | Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit). Gene symbol: GRID2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61625 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRID2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Dai J, et al. "GluD1 is a signal transduction device disguised as an ionotropic receptor" Nature. 2021 Jul;595(7866):261-265 PMID:34135511 |
| Figure(s): | Figure 4, S10 |
| Annotation description: | Authors show that NRXN1(SS4+) and NRXN3(SS4+) regulate NMDARs and AMPARs via the cerebellin-dependent activation of GluDs that transduce distinct presynaptic neurexin signals into different postsynaptic receptor responses. The Neurexin alternative splicing site 4 (SS4) is critical to these signaling pathways. Figure 4,5: Minimal GluD1 (GRID1) and GluD2 (GRID2) constructs containing only their N-terminal cerebellin-binding and C-terminal cytoplasmic domains, joined by an unrelated transmembrane region (of CD4), referred to as GluD1-CD4TMR and GluD2-CD4TMR fully control the levels of NMDA and AMPA receptors. AMPA/NMDA ratio phenotypes of GluD1 knockout1 mice were fully rescued by expressing wildtype GluD1, wildtype GluD2 and the "CD4TMR" constructs thereof. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | structures for GluD1 (GRID1), GluD2 (GRID2), Cbln1, Cbln1-GluD2 complex, β-NRX1-Cbln1-GluD2 complex @ PMID:27418511 |
| SynGO annotation ID: | 4999 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |