| Annotated protein: | Neogenin. Gene symbol: NEO1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97798 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NEO1 |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling, modulating synaptic transmission (GO:0099550) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Liakath-Ali K, et al. "Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus" Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2123421119 PMID:35544694 |
| Figure(s): | Figure 2, 4, 5 |
| Annotation description: | Figure 4: Neo1 binds in trans to Cbln4/Nrxn1α-SS4+ complexes, forming bona fide adhesion complexes. Figure 2: Cbln4 deletion in the EC selectively blocks LTP at EC→DG synapses. (EC = entorhinal cortex, DG = dentate gyrus). Figure 5: Postsynaptic deletion of Neo1 in the DG severely impaired LTP in EC→DG synapses of both MPP (Fig. 5 E-G) and LPP connections (Fig. 5 H-J), similar to the presynaptic deletion of Cbln4 in the EC (Fig. 1). Authors conclude that "binding of cerebellin-4 (Cbln4), a secreted ligand of presynaptic neurexin adhesion molecules, to neogenin-1, a postsynaptic surface protein known as a developmental netrin receptor, is essential for normal LTP at entorhinal cortex→dentate gyrus synapses in mice. Cbln4 and neogenin-1 are dispensable for basal synaptic transmission and not involved in establishing synaptic connections as such." |
| Evidence tracking, Biological System: | Cell-free system Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Neo1 modulates synaptic transmission (induction and maintenance of LTP) in basolateral amygdala of mice @ PMID:30228230 |
| SynGO annotation ID: | 4990 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |