| Annotated protein: | E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb protein X 1) (Ligand of Numb-binding protein 1) (Numb-binding protein 1) (RING-type E3 ubiquitin transferase LNX). Gene symbol: LNX1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O70263 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LNX1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Annotated paper: | Liu XD, et al. "Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1" J Cell Biol. 2018 Nov 5;217(11):4007-4024 PMID:30185604 |
| Figure(s): | Figure S2 |
| Annotation description: | Figure S2B: Lnx1 was detected in PSD biochemical fractions from mouse hippocampi. The antibody shows an unspecific band, the other band (presumably Lnx1) is abolished in controls using Lnx1 -/- mice. Figure S2C: confocal imaging of Thy1-GFP-M, synapsin1 and overexpressed Flag-Lnx1 in cultured hippocampal neurons showed localization to dendritic spines. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Biochemical fractionation (generic) Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4985 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |