| Annotated protein: | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) (Nogo66 receptor-1) (NgR1). Gene symbol: RTN4R. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99PI8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RTN4R |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse assembly (GO:0051963) |
| Synapse type(s): | cerebral cortex, glutamatergic forebrain, glutamatergic |
| Annotated paper: | Karlsson TE, et al. "NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity" Cereb Cortex. 2016 Apr;26(4):1804-17 PMID:26838771 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4: using light microscopy and software assistance to categorized and count dendritic spines, authors observed that NgR1 (Nogo receptor-1, gene RTN4R) overexpression limits the number of mature mushroom spines in-vivo in neurons from frontal association cortex, the cingulate cortex, and nucleus accumbens regions of mouse brains. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4984 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |