| Annotated protein: | Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC) (Protein CRTAC1-B). Gene symbol: CRTAC1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R555 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CRTAC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Nishida R, et al. "LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation" Sci Rep. 2021 Mar 3;11(1):5085 PMID:33658590 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1d: STED super-resolution microscopy of double immunofluorescence labeling for LOTUS (CRTAC1) and PSD-95 (DLG4) in cultured hippocampal mouse neurons showed partial co-localization at the postsynaptic density. Using the same techniques, Bassoon (BSN, a presynaptic active zone protein) showed proximate localization to LOTUS but a lower rate of co-localization (than LOTUS with PSD-95). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4982 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |