| Annotated protein: | Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1). Gene symbol: TACR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P14600 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TACR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | spinal cord |
| Annotated paper: | Liu H, et al. "Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors" Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1009-13 PMID:7508118 |
| Figure(s): | Figure 2 |
| Annotation description: | EM imaging showed both substance P (SP, gene TAC1) and substance P receptor (SPR, gene TACR1) were localized at synapses, but not exclusive to synapses. Figure 2d,e: Electron microscopic double labeling of SP and SPR showed localization to GABAergic synapses in the superficial dorsal horn. SP was observed at presynaptic dense core vesicles (DCV), but not at synaptic vesicles. SPR was observed throughout the postsynaptic site. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4979 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |