| Annotated protein: | Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein). Gene symbol: CDC42. Taxonomy: Mus musculus (Mouse). Uniprot ID: P60766 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDC42 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Shibata ACE, et al. "Photoactivatable CaMKII induces synaptic plasticity in single synapses" Nat Commun. 2021 Feb 2;12(1):751 PMID:33531495 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6b: "Fluorescence lifetime images of Cdc42 activity upon paCaMKII activation in clustered (multiple) spines. paCaMKII was sequentially activated in five to eight spines for each neuron by two-photon excitation at 820 nm in indicated spines" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | FRET |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 3: Role of Cdc42-palm in dendritic spine induction. @ PMID:19092927 |
| SynGO annotation ID: | 4971 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |