| Annotated protein: | Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II). Gene symbol: NPTX2. Taxonomy: Mus musculus (Mouse). Uniprot ID: O70340 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTX2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | spinal cord |
| Annotated paper: | Kanehisa K, et al. "Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch" Nat Commun. 2022 May 2;13(1):2367 PMID:35501343 |
| Figure(s): | Figure 2h |
| Annotation description: | Figure 2h: Electron microscopy analysis of neuronal pentraxin-2 (NPTX2) showed immunogold particles at presynaptic terminals connected to a postsynapse expressing gastrin-releasing peptide receptors (GRPRs) in the spinal dorsal horn. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4970 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |